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The Nrf2-Antioxidant Response Element SignallingPathway Controls Fibrosis and Autoimmunity in Scleroderma.
Dysregulationsintheoxidant/antioxidantbalanceareknowntobemajorfactorsinthepathogenesisofsystemicsclerosis(SSc).NRF2actsasakeyplayerintheantioxidantdefensebycontrollingthetranscriptionofantioxidantandcytoprotectivegenes.Inthisarticle,theauthorsexploredtheinvolvementofadown-expressionofNRF2inthepathogenesisofSScandtherelevanceofaNRF2agonist,asapotenttherapeuticoptioninSSc.