Project Description

This first edition of the clinical science journal club of the EUSTAR Young Investigators (YIG) summarizes some of the recent studies that have been published regarding systemic sclerosis related renal crisis. Scleroderma renal crisis (SRC) is a rare but potentially life‐threatening complication of systemic sclerosis (SSc). SRC is described to occur in approximately 5% of all patients. Before introduction of angiotensin-converting enzyme (ACE)-inhibitors (ACEi) as treatment SRC was the leading cause of death in SSc. But also nowadays, SRC is still a feared complication of SSc with considerable risk for mortality and loss of kidney function. The clinical picture at first presentation may differ between patients complicating early and adequate diagnosis. In addition, the absence of a gold standard complicates early and uniform identification of patients with SRC, and also complicates the research how to further improve this severe complication.

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