Poly(ADP-ribose) polymerase-1 (PARP-1) regulates fibroblast activation
in systemic sclerosis.
The enzyme poly(ADP-ribose) polymerase-1 also called PARP-1, is
a member of the PARP family, a group of 18 enzymes that transfer
ADP-ribose groups onto various substrate proteins. This
mechanism called PARylation, exerts profound regulatory effects
on many physiological and pathological processes. Among PARPs,
PARP-1 is by far the most well characterized and it has been
recently shown that PARP-1 could PARylate Smad proteins. As
Smad proteins take part in TGFβ signaling, a key pathway involved
in the pathogenesis of fibrosis is systemic sclerosis (SSc),
modulation of PARP-1 and PARylation may also have regulatory
effects on fibrosis. In this article, the authors have explored the
links between PARP-1 and TGFβ signaling and the impact of a
modulation of PARP-1-dependent PARylation on fibrosis both in
vitro and in vivo.