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BASIC SCIENCE JOURNAL CLUB OF EUSTAR YIG May-August 2019

2019-10-22T10:06:21+02:00

May CXCL4 assembles DNA into liquid crystalline complexes to amplify TLR9-mediated interferon-α production in systemic sclerosis. June Blockade of the CX3CL1-CX3CR1 Pathway Inhibits the Progress of Skin Inflammation, Fibrosis, and Vascular Injury in an Experimental Mouse Model of Systemic Sclerosis July Microparticles in systemic sclerosis: Potential pro-inflammatory mediators and pulmonary hypertension biomarkers. August Activation of [...]

BASIC SCIENCE JOURNAL CLUB OF EUSTAR YIG SEP DEC 2018

2019-10-22T09:47:52+02:00

READ MORE The Nrf2-Antioxidant Response Element SignallingPathway Controls Fibrosis and Autoimmunity in Scleroderma. Dysregulationsintheoxidant/antioxidantbalanceareknowntobemajorfactorsinthepathogenesisofsystemicsclerosis(SSc).NRF2actsasakeyplayerintheantioxidantdefensebycontrollingthetranscriptionofantioxidantandcytoprotectivegenes.Inthisarticle,theauthorsexploredtheinvolvementofadown-expressionofNRF2inthepathogenesisofSScandtherelevanceofaNRF2agonist,asapotenttherapeuticoptioninSSc.

BASIC SCIENCE JOURNAL CLUB OF EUSTAR YIG May–Aug 2018

2019-10-21T22:46:14+02:00

READ MORE May 2018 Poly(ADP-ribose) polymerase-1 (PARP-1) regulates fibroblast activation in systemic sclerosis. The enzyme poly(ADP-ribose) polymerase-1 also called PARP-1, is a member of the PARP family, a group of 18 enzymes that transfer ADP-ribose groups onto various substrate proteins. This mechanism called PARylation, exerts profound regulatory effects on many physiological and pathological processes. Among [...]

BASIC SCIENCE JOURNAL CLUB OF EUSTAR YIG Jan-Apr 2018

2019-10-21T22:46:56+02:00

January2018 The histone demethylase Jumonji domain-containing protein 3 (JMJD3) regulates fibroblast activation in systemic sclerosis. In this article, the authors explored the role of the Jumonji domain-containing protein 3 (JMJD3) and the ubiquitously transcribed tetratricopeptide repeat on chromosome X (UTX), two highly specific histone–demethylases which could participate to the constitutively activated state of SSc fibroblasts. [...]