e-Masterclass on ILD in SSc Japan, November 13th, 2020 Kindly note that the time is in JST (UTC +9) DOWNLOAD THE PROGRAM ORGANIZER: PROF. MASATAKA KUWANA Japan College of Rheumatology On demand pre-recorded lectures available from October 30th, 2020 to November 13th, 2020 Opening [...]
e-Masterclass on ILD in SSc Japan, November 13th, 2020 Kindly note that the time is in JST (UTC +9) DOWNLOAD THE PROGRAM REGISTRATION TO THE MASTERCLASS PLATFORM ORGANIZER: PROF. MASATAKA KUWANA Japan College of Rheumatology On demand pre-recorded lectures available [...]
May CXCL4 assembles DNA into liquid crystalline complexes to amplify TLR9-mediated interferon-α production in systemic sclerosis. June Blockade of the CX3CL1-CX3CR1 Pathway Inhibits the Progress of Skin Inflammation, Fibrosis, and Vascular Injury in an Experimental Mouse Model of Systemic Sclerosis July Microparticles in systemic sclerosis: Potential pro-inflammatory mediators and pulmonary hypertension biomarkers. August Activation of [...]
January Attenuation of murine sclerodermatous models by the selective S1P1 receptor modulator cenerimod READ MORE
READ MORE The Nrf2-Antioxidant Response Element SignallingPathway Controls Fibrosis and Autoimmunity in Scleroderma. Dysregulationsintheoxidant/antioxidantbalanceareknowntobemajorfactorsinthepathogenesisofsystemicsclerosis(SSc).NRF2actsasakeyplayerintheantioxidantdefensebycontrollingthetranscriptionofantioxidantandcytoprotectivegenes.Inthisarticle,theauthorsexploredtheinvolvementofadown-expressionofNRF2inthepathogenesisofSScandtherelevanceofaNRF2agonist,asapotenttherapeuticoptioninSSc.
READ MORE May 2018 Poly(ADP-ribose) polymerase-1 (PARP-1) regulates fibroblast activation in systemic sclerosis. The enzyme poly(ADP-ribose) polymerase-1 also called PARP-1, is a member of the PARP family, a group of 18 enzymes that transfer ADP-ribose groups onto various substrate proteins. This mechanism called PARylation, exerts profound regulatory effects on many physiological and pathological processes. Among [...]
January2018 The histone demethylase Jumonji domain-containing protein 3 (JMJD3) regulates fibroblast activation in systemic sclerosis. In this article, the authors explored the role of the Jumonji domain-containing protein 3 (JMJD3) and the ubiquitously transcribed tetratricopeptide repeat on chromosome X (UTX), two highly specific histone–demethylases which could participate to the constitutively activated state of SSc fibroblasts. [...]
This second edition of the clinical science journal club of the EUSTAR Young Investigators (YIG) summarizes some of the recent advances in Systemic Sclerosis related Interstitial Lung Disease (SSc-ILD). ILD is a relatively frequent complication in SSc, representing one of the main causes of morbidity and mortality. Current treatments for ILD include Cyclophosphamide and [...]