Descrizione Progetto

READ MORE

The Nrf2-Antioxidant Response Element SignallingPathway Controls Fibrosis and Autoimmunity in Scleroderma.
Dysregulationsintheoxidant/antioxidantbalanceareknowntobemajorfactorsinthepathogenesisofsystemicsclerosis(SSc).NRF2actsasakeyplayerintheantioxidantdefensebycontrollingthetranscriptionofantioxidantandcytoprotectivegenes.Inthisarticle,theauthorsexploredtheinvolvementofadown-expressionofNRF2inthepathogenesisofSScandtherelevanceofaNRF2agonist,asapotenttherapeuticoptioninSSc.